|
KMID : 1123920190330060341
|
|
Korean Journal of Oriental Physiology and Pathology
2019 Volume.33 No. 6 p.341 ~ p.348
|
|
|
Study on the Improvement Effect of Antibacterial and Allergic Contact Dermatitis on Torreyae Semen Extracts
|
|
Choi Chan-Hun
Lee Soong-In
Yim Soon-Ho
Jung Hyun-Woo
|
|
|
Abstract
|
|
|
|
The purpose of this study was to investigate the efficacy of Torreyae semen extract against antimicrobial and allergic contact dermatitis to explore its utility as a herbal resource. To this end, the antibacterial effects of Torreyae Semend extracted with hot water and ethanol (30%, 60%, 90%) were investigated using Staphylococcus aureus, Staphylococcus epidermidis, pseudomonas aeruginosa, and Propionibacterium acnes. And observed the anti-atopic dermatitis efficacy with a mouse model that allergic contact dermatitis induced by DNCB. Experimental results showed that the antibacterial activity against S. epidermidis and P. aeruginosa was significantly higher in the hot water extract of Torreyae Semen. We observed that the extracts of 30% ethanol and hot water of Torreyae Semen inhibited growth in a concentration-dependent manner in P. acnes & S. epidermidis. We observed that the administration of hot water extracts and 30% ethanol extract of Torreyae Semen significantly reduce the thickness of ear & back and gross skin condition compared to the control group in the mice with allergic contact dermatitis. As a result of H & E histological staining, it was observed that the Torreyae Semen extraction group had markedly reduced epidermis and skin thickness, granules, and keratinization compared to the control group. The groups administrated with Torreyae Semen hot water extracts had decreased TNF-α and IL-10 contents compared with the control group. As a result, Torreyae Semen may be used as a useful herbal resource because it has a certain level of antibacterial and anti-atopic effects.
|
|
|
KEYWORD
|
|
|
Torreyae Semen, antibacterial, allergic contact dermatitis, Hot water extraction, and Ethanol extraction
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|